A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
Identifieur interne : 00A176 ( Main/Exploration ); précédent : 00A175; suivant : 00A177A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
Auteurs : Patricia L. M. Dahia [États-Unis] ; Ken N. Ross [États-Unis] ; Matthew E. Wright [États-Unis] ; César Y. Hayashida [Brésil] ; Sandro Santagata [États-Unis] ; Marta Barontini [Argentine] ; Andrew L. Kung [États-Unis] ; Gabriela Sanso [Argentine] ; James F. Powers [États-Unis] ; Arthur S. Tischler [États-Unis] ; Richard Hodin [États-Unis] ; Shannon Heitritter [États-Unis] ; Francis Moore [États-Unis] ; Robert Dluhy [États-Unis] ; Julie Ann Sosa [États-Unis] ; I. Tolgay Ocal [États-Unis] ; Diana E. Benn [Australie] ; Deborah J. Marsh [Australie] ; Bruce G. Robinson [Australie] ; Katherine Schneider [États-Unis] ; Judy Garber [États-Unis] ; Seth M. Arum [États-Unis] ; Márta Korbonits [Royaume-Uni] ; Ashley Grossman [Royaume-Uni] ; Pascal Pigny [France] ; Sérgio P. A. Toledo [Brésil] ; Vania Nosé [États-Unis] ; Cheng Li [États-Unis] ; Charles D. Stiles [États-Unis]Source :
- PLoS Genetics [ 1553-7390 ] ; 2005.
Abstract
Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions
Url:
DOI: 10.1371/journal.pgen.0010008
PubMed: 16103922
PubMed Central: 1183527
Affiliations:
- Argentine, Australie, Brésil, France, Royaume-Uni, États-Unis
- Angleterre, Connecticut, Grand Londres, Hauts-de-France, Massachusetts, Nord-Pas-de-Calais, Nouvelle-Galles du Sud, État de São Paulo
- Lille, Londres, Sydney, São Paulo
- Université de Sydney
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Le document en format XML
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Robinson</name><affiliation wicri:level="4"><nlm:aff id="aff10"> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Schneider, Katherine" sort="Schneider, Katherine" uniqKey="Schneider K" first="Katherine" last="Schneider">Katherine Schneider</name><affiliation wicri:level="2"><nlm:aff id="aff11"> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation wicri:level="2"><nlm:aff id="aff11"> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Arum, Seth M" sort="Arum, Seth M" uniqKey="Arum S" first="Seth M" last="Arum">Seth M. Arum</name><affiliation wicri:level="2"><nlm:aff id="aff12"> Boston Medical Center, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Boston Medical Center, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Korbonits, Marta" sort="Korbonits, Marta" uniqKey="Korbonits M" first="Márta" last="Korbonits">Márta Korbonits</name><affiliation wicri:level="3"><nlm:aff id="aff13"> St. Bartholomew's Hospital, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> St. Bartholomew's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Grossman, Ashley" sort="Grossman, Ashley" uniqKey="Grossman A" first="Ashley" last="Grossman">Ashley Grossman</name><affiliation wicri:level="3"><nlm:aff id="aff13"> St. Bartholomew's Hospital, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> St. Bartholomew's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pigny, Pascal" sort="Pigny, Pascal" uniqKey="Pigny P" first="Pascal" last="Pigny">Pascal Pigny</name><affiliation wicri:level="3"><nlm:aff id="aff14"> Regional University Hospital, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Regional University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Toledo, Sergio P A" sort="Toledo, Sergio P A" uniqKey="Toledo S" first="Sérgio P. A" last="Toledo">Sérgio P. A. Toledo</name><affiliation wicri:level="3"><nlm:aff id="aff3"> University of São Paulo School of Medicine, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> University of São Paulo School of Medicine, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Nose, Vania" sort="Nose, Vania" uniqKey="Nose V" first="Vania" last="Nosé">Vania Nosé</name><affiliation wicri:level="2"><nlm:aff id="aff4"> Brigham and Women's Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Cheng" sort="Li, Cheng" uniqKey="Li C" first="Cheng" last="Li">Cheng Li</name><affiliation wicri:level="2"><nlm:aff id="aff15"> Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stiles, Charles D" sort="Stiles, Charles D" uniqKey="Stiles C" first="Charles D" last="Stiles">Charles D. Stiles</name><affiliation wicri:level="2"><nlm:aff id="aff1"> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16103922</idno><idno type="pmc">1183527</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183527</idno><idno type="RBID">PMC:1183527</idno><idno type="doi">10.1371/journal.pgen.0010008</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">002862</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002862</idno><idno type="wicri:Area/Pmc/Curation">002712</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002712</idno><idno type="wicri:Area/Pmc/Checkpoint">002C70</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002C70</idno><idno type="wicri:Area/Ncbi/Merge">000148</idno><idno type="wicri:Area/Ncbi/Curation">000148</idno><idno type="wicri:Area/Ncbi/Checkpoint">000148</idno><idno type="wicri:doubleKey">1553-7390:2005:Dahia P:a:hif:regulatory</idno><idno type="wicri:Area/Main/Merge">00AD40</idno><idno type="wicri:Area/Main/Curation">00A176</idno><idno type="wicri:Area/Main/Exploration">00A176</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas</title><author><name sortKey="Dahia, Patricia L M" sort="Dahia, Patricia L M" uniqKey="Dahia P" first="Patricia L. M" last="Dahia">Patricia L. M. Dahia</name><affiliation wicri:level="2"><nlm:aff id="aff1"> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ross, Ken N" sort="Ross, Ken N" uniqKey="Ross K" first="Ken N" last="Ross">Ken N. Ross</name><affiliation wicri:level="2"><nlm:aff id="aff2"> Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wright, Matthew E" sort="Wright, Matthew E" uniqKey="Wright M" first="Matthew E" last="Wright">Matthew E. Wright</name><affiliation wicri:level="2"><nlm:aff id="aff1"> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hayashida, Cesar Y" sort="Hayashida, Cesar Y" uniqKey="Hayashida C" first="César Y" last="Hayashida">César Y. Hayashida</name><affiliation wicri:level="3"><nlm:aff id="aff3"> University of São Paulo School of Medicine, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> University of São Paulo School of Medicine, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Santagata, Sandro" sort="Santagata, Sandro" uniqKey="Santagata S" first="Sandro" last="Santagata">Sandro Santagata</name><affiliation wicri:level="2"><nlm:aff id="aff4"> Brigham and Women's Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Barontini, Marta" sort="Barontini, Marta" uniqKey="Barontini M" first="Marta" last="Barontini">Marta Barontini</name><affiliation wicri:level="1"><nlm:aff id="aff5"> Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea> Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Kung, Andrew L" sort="Kung, Andrew L" uniqKey="Kung A" first="Andrew L" last="Kung">Andrew L. Kung</name><affiliation wicri:level="2"><nlm:aff id="aff6"> Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sanso, Gabriela" sort="Sanso, Gabriela" uniqKey="Sanso G" first="Gabriela" last="Sanso">Gabriela Sanso</name><affiliation wicri:level="1"><nlm:aff id="aff5"> Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea> Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Powers, James F" sort="Powers, James F" uniqKey="Powers J" first="James F" last="Powers">James F. Powers</name><affiliation wicri:level="2"><nlm:aff id="aff7"> Tufts–New England Medical Center, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Tufts–New England Medical Center, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Tischler, Arthur S" sort="Tischler, Arthur S" uniqKey="Tischler A" first="Arthur S" last="Tischler">Arthur S. Tischler</name><affiliation wicri:level="2"><nlm:aff id="aff7"> Tufts–New England Medical Center, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Tufts–New England Medical Center, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hodin, Richard" sort="Hodin, Richard" uniqKey="Hodin R" first="Richard" last="Hodin">Richard Hodin</name><affiliation wicri:level="2"><nlm:aff id="aff8"> Massachusetts General Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Heitritter, Shannon" sort="Heitritter, Shannon" uniqKey="Heitritter S" first="Shannon" last="Heitritter">Shannon Heitritter</name><affiliation wicri:level="2"><nlm:aff id="aff4"> Brigham and Women's Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Moore, Francis" sort="Moore, Francis" uniqKey="Moore F" first="Francis" last="Moore">Francis Moore</name><affiliation wicri:level="2"><nlm:aff id="aff4"> Brigham and Women's Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dluhy, Robert" sort="Dluhy, Robert" uniqKey="Dluhy R" first="Robert" last="Dluhy">Robert Dluhy</name><affiliation wicri:level="2"><nlm:aff id="aff4"> Brigham and Women's Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sosa, Julie Ann" sort="Sosa, Julie Ann" uniqKey="Sosa J" first="Julie Ann" last="Sosa">Julie Ann Sosa</name><affiliation wicri:level="2"><nlm:aff id="aff9"> Yale University, New Haven, Connecticut, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Yale University, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Ocal, I Tolgay" sort="Ocal, I Tolgay" uniqKey="Ocal I" first="I. Tolgay" last="Ocal">I. Tolgay Ocal</name><affiliation wicri:level="2"><nlm:aff id="aff9"> Yale University, New Haven, Connecticut, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Yale University, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Benn, Diana E" sort="Benn, Diana E" uniqKey="Benn D" first="Diana E" last="Benn">Diana E. Benn</name><affiliation wicri:level="4"><nlm:aff id="aff10"> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Marsh, Deborah J" sort="Marsh, Deborah J" uniqKey="Marsh D" first="Deborah J" last="Marsh">Deborah J. Marsh</name><affiliation wicri:level="4"><nlm:aff id="aff10"> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Robinson, Bruce G" sort="Robinson, Bruce G" uniqKey="Robinson B" first="Bruce G" last="Robinson">Bruce G. Robinson</name><affiliation wicri:level="4"><nlm:aff id="aff10"> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Schneider, Katherine" sort="Schneider, Katherine" uniqKey="Schneider K" first="Katherine" last="Schneider">Katherine Schneider</name><affiliation wicri:level="2"><nlm:aff id="aff11"> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><affiliation wicri:level="2"><nlm:aff id="aff11"> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Arum, Seth M" sort="Arum, Seth M" uniqKey="Arum S" first="Seth M" last="Arum">Seth M. Arum</name><affiliation wicri:level="2"><nlm:aff id="aff12"> Boston Medical Center, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Boston Medical Center, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Korbonits, Marta" sort="Korbonits, Marta" uniqKey="Korbonits M" first="Márta" last="Korbonits">Márta Korbonits</name><affiliation wicri:level="3"><nlm:aff id="aff13"> St. Bartholomew's Hospital, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> St. Bartholomew's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Grossman, Ashley" sort="Grossman, Ashley" uniqKey="Grossman A" first="Ashley" last="Grossman">Ashley Grossman</name><affiliation wicri:level="3"><nlm:aff id="aff13"> St. Bartholomew's Hospital, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> St. Bartholomew's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pigny, Pascal" sort="Pigny, Pascal" uniqKey="Pigny P" first="Pascal" last="Pigny">Pascal Pigny</name><affiliation wicri:level="3"><nlm:aff id="aff14"> Regional University Hospital, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Regional University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Toledo, Sergio P A" sort="Toledo, Sergio P A" uniqKey="Toledo S" first="Sérgio P. A" last="Toledo">Sérgio P. A. Toledo</name><affiliation wicri:level="3"><nlm:aff id="aff3"> University of São Paulo School of Medicine, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> University of São Paulo School of Medicine, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Nose, Vania" sort="Nose, Vania" uniqKey="Nose V" first="Vania" last="Nosé">Vania Nosé</name><affiliation wicri:level="2"><nlm:aff id="aff4"> Brigham and Women's Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Cheng" sort="Li, Cheng" uniqKey="Li C" first="Cheng" last="Li">Cheng Li</name><affiliation wicri:level="2"><nlm:aff id="aff15"> Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stiles, Charles D" sort="Stiles, Charles D" uniqKey="Stiles C" first="Charles D" last="Stiles">Charles D. Stiles</name><affiliation wicri:level="2"><nlm:aff id="aff1"> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Genetics</title><idno type="ISSN">1553-7390</idno><idno type="eISSN">1553-7404</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions<italic>.</italic> We show here a functional link between tumors with <italic>VHL</italic> mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD). A transcription profile of reduced oxidoreductase is detected in all three of these tumor types, together with an angiogenesis/hypoxia profile typical of VHL dysfunction. The oxidoreductase defect, not previously detected in <italic>VHL</italic>-null tumors, is explained by suppression of the SDHB protein, a component of mitochondrial complex II. The decrease in SDHB is also noted in tumors with <italic>SDHD</italic> mutations. Gain-of-function and loss-of-function analyses show that the link between hypoxia signals (via VHL) and mitochondrial signals (via SDH) is mediated by HIF1α. These findings explain the shared features of pheochromocytomas with <italic>VHL</italic> and <italic>SDH</italic> mutations and suggest an additional mechanism for increased HIF1α activity in tumors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Manger, Wm" uniqKey="Manger W">WM Manger</name></author><author><name sortKey="Gifford, Rw" uniqKey="Gifford R">RW Gifford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name></author><author><name sortKey="Farmer, J" uniqKey="Farmer J">J Farmer</name></author><author><name sortKey="Kessler, Lj" uniqKey="Kessler L">LJ Kessler</name></author><author><name sortKey="Townsend, Rr" uniqKey="Townsend R">RR Townsend</name></author><author><name sortKey="Nathanson, Kl" uniqKey="Nathanson K">KL Nathanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaelin, Wg" uniqKey="Kaelin W">WG 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Mootha</name></author><author><name sortKey="Bunkenborg, J" uniqKey="Bunkenborg J">J Bunkenborg</name></author><author><name sortKey="Olsen, Jv" uniqKey="Olsen J">JV Olsen</name></author><author><name sortKey="Hjerrild, M" uniqKey="Hjerrild M">M Hjerrild</name></author><author><name sortKey="Wisniewski, Jr" uniqKey="Wisniewski J">JR Wisniewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Semenza, G" uniqKey="Semenza G">G Semenza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eng, C" uniqKey="Eng C">C Eng</name></author><author><name sortKey="Crossey, Pa" uniqKey="Crossey P">PA Crossey</name></author><author><name sortKey="Mulligan, Lm" uniqKey="Mulligan L">LM Mulligan</name></author><author><name sortKey="Healey, Cs" uniqKey="Healey C">CS Healey</name></author><author><name sortKey="Houghton, C" uniqKey="Houghton C">C Houghton</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Ratcliffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanellopoulou, C" uniqKey="Kanellopoulou C">C Kanellopoulou</name></author><author><name sortKey="Muljo, Sa" uniqKey="Muljo S">SA Muljo</name></author><author><name sortKey="Kung, Al" uniqKey="Kung A">AL Kung</name></author><author><name sortKey="Ganesan, S" uniqKey="Ganesan S">S Ganesan</name></author><author><name sortKey="Drapkin, R" uniqKey="Drapkin R">R Drapkin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Argentine</li><li>Australie</li><li>Brésil</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Connecticut</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Galles du Sud</li><li>État de São Paulo</li></region><settlement><li>Lille</li><li>Londres</li><li>Sydney</li><li>São Paulo</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Dahia, Patricia L M" sort="Dahia, Patricia L M" uniqKey="Dahia P" first="Patricia L. M" last="Dahia">Patricia L. M. Dahia</name></region><name sortKey="Arum, Seth M" sort="Arum, Seth M" uniqKey="Arum S" first="Seth M" last="Arum">Seth M. Arum</name><name sortKey="Dluhy, Robert" sort="Dluhy, Robert" uniqKey="Dluhy R" first="Robert" last="Dluhy">Robert Dluhy</name><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name><name sortKey="Heitritter, Shannon" sort="Heitritter, Shannon" uniqKey="Heitritter S" first="Shannon" last="Heitritter">Shannon Heitritter</name><name sortKey="Hodin, Richard" sort="Hodin, Richard" uniqKey="Hodin R" first="Richard" last="Hodin">Richard Hodin</name><name sortKey="Kung, Andrew L" sort="Kung, Andrew L" uniqKey="Kung A" first="Andrew L" last="Kung">Andrew L. Kung</name><name sortKey="Li, Cheng" sort="Li, Cheng" uniqKey="Li C" first="Cheng" last="Li">Cheng Li</name><name sortKey="Moore, Francis" sort="Moore, Francis" uniqKey="Moore F" first="Francis" last="Moore">Francis Moore</name><name sortKey="Nose, Vania" sort="Nose, Vania" uniqKey="Nose V" first="Vania" last="Nosé">Vania Nosé</name><name sortKey="Ocal, I Tolgay" sort="Ocal, I Tolgay" uniqKey="Ocal I" first="I. Tolgay" last="Ocal">I. Tolgay Ocal</name><name sortKey="Powers, James F" sort="Powers, James F" uniqKey="Powers J" first="James F" last="Powers">James F. Powers</name><name sortKey="Ross, Ken N" sort="Ross, Ken N" uniqKey="Ross K" first="Ken N" last="Ross">Ken N. Ross</name><name sortKey="Santagata, Sandro" sort="Santagata, Sandro" uniqKey="Santagata S" first="Sandro" last="Santagata">Sandro Santagata</name><name sortKey="Schneider, Katherine" sort="Schneider, Katherine" uniqKey="Schneider K" first="Katherine" last="Schneider">Katherine Schneider</name><name sortKey="Sosa, Julie Ann" sort="Sosa, Julie Ann" uniqKey="Sosa J" first="Julie Ann" last="Sosa">Julie Ann Sosa</name><name sortKey="Stiles, Charles D" sort="Stiles, Charles D" uniqKey="Stiles C" first="Charles D" last="Stiles">Charles D. Stiles</name><name sortKey="Tischler, Arthur S" sort="Tischler, Arthur S" uniqKey="Tischler A" first="Arthur S" last="Tischler">Arthur S. Tischler</name><name sortKey="Wright, Matthew E" sort="Wright, Matthew E" uniqKey="Wright M" first="Matthew E" last="Wright">Matthew E. Wright</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Hayashida, Cesar Y" sort="Hayashida, Cesar Y" uniqKey="Hayashida C" first="César Y" last="Hayashida">César Y. Hayashida</name></region><name sortKey="Toledo, Sergio P A" sort="Toledo, Sergio P A" uniqKey="Toledo S" first="Sérgio P. A" last="Toledo">Sérgio P. A. Toledo</name></country><country name="Argentine"><noRegion><name sortKey="Barontini, Marta" sort="Barontini, Marta" uniqKey="Barontini M" first="Marta" last="Barontini">Marta Barontini</name></noRegion><name sortKey="Sanso, Gabriela" sort="Sanso, Gabriela" uniqKey="Sanso G" first="Gabriela" last="Sanso">Gabriela Sanso</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Benn, Diana E" sort="Benn, Diana E" uniqKey="Benn D" first="Diana E" last="Benn">Diana E. Benn</name></region><name sortKey="Marsh, Deborah J" sort="Marsh, Deborah J" uniqKey="Marsh D" first="Deborah J" last="Marsh">Deborah J. Marsh</name><name sortKey="Robinson, Bruce G" sort="Robinson, Bruce G" uniqKey="Robinson B" first="Bruce G" last="Robinson">Bruce G. Robinson</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Korbonits, Marta" sort="Korbonits, Marta" uniqKey="Korbonits M" first="Márta" last="Korbonits">Márta Korbonits</name></region><name sortKey="Grossman, Ashley" sort="Grossman, Ashley" uniqKey="Grossman A" first="Ashley" last="Grossman">Ashley Grossman</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Pigny, Pascal" sort="Pigny, Pascal" uniqKey="Pigny P" first="Pascal" last="Pigny">Pascal Pigny</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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